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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TQ0184 | Chebulinic acid | ATPase , Proton pump , DNA/RNA Synthesis , Antibacterial , TGF-beta/Smad | |
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity. | |||
T1748 | Kartogenin | KGN | TGF-beta/Smad |
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. | |||
T5197 | BIBF0775 | ALK , TGF-beta/Smad | |
BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM). | |||
T2123 | LY2109761 | Autophagy , TGF-beta/Smad | |
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2. | |||
T2462 | SB-505124 | ALK , TGF-beta/Smad | |
SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5. | |||
T4975 | SM 16 | ALK , TGF-beta/Smad | |
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM). | |||
T4662 | SJ000291942 | TGF-beta/Smad | |
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. | |||
TN2081 | Maohuoside A | MAPK | |
Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways. | |||
T1800 | GW788388 | GW 788388 | ALK , TGF-beta/Smad |
GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities. | |||
T1763 | SB 525334 | SB525334 | ALK , TGF-beta/Smad |
SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM). | |||
T16708 | R-268712 | ALK , TGF-beta/Smad | |
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor. | |||
T1942 | DMH-1 | DMH1 | ALK , Autophagy , TGF-beta/Smad |
DMH-1 is a potent and selective BMP inhibitor. | |||
T1914 | K02288 | K 02288 | ALK , TGF-beta/Smad |
K 02288 is a novel small molecule inhibitor of ALK1/2/3/6. | |||
T4283 | SRI-011381 | TGF-beta/Smad | |
SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease. | |||
T2510 | Galunisertib | LY2157299 | TGF-beta/Smad |
Galunisertib (LY2157299) is an orally available inhibitor of TGFβRI kinase (IC50: 56 nM) with potential antineoplastic activity. | |||
T23127 | PD-161570 | PD 161570 | EGFR , FGFR , PDGFR , Src |
PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, a... | |||
T1943 | ML347 | LDN 193719 | ALK , TGF-beta/Smad |
ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3. | |||
T2754 | Oxymatrine | Oxysophoridine,Matrine N-oxide | Influenza Virus , Autophagy , TGF-beta/Smad |
Oxymatrine (Oxysophoridine) is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis B virus.It can also inhibit iNOS expressio... | |||
T1449 | Hydrochlorothiazide | HCTZ | Potassium Channel , Carbonic Anhydrase , TGF-beta/Smad |
Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis. | |||
T13741 | Isoviolanthin | Others | |
Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells without cytotoxic effects on normal live cells and has potential as a therapeutic agent for the treatment of advanced-stage metastat... |